Saumya Patel - все книги по циклам и сериям | Книги по порядку

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.

This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.

Biostatistical analysis was carried out with Statistical Package for Social Sciences (SPSS) software to understand the significance of different signs and symptoms observed in Spondyloarthritis disease with specific geographic location to Gujarat, India. A Bioinformatics study was also carried out with investigational Dihyrofolate reductase (DHFR) inhibitors reported in Toxoplasma gondii and Lactobacillus casei using 2D- Quantitative Structure Activity Relationship (QSAR). Best scoring inhibitors from 2D-QSAR study provides new insight for designing optimized drugs to combat the disease.